A novel green process for synthesis of venlafaxine and its impurities
نویسندگان
چکیده
Research Article 2017 January, Vol.5 (1): 56 – 63 © Copy Right, 2017 A novel green process for synthesis of venlafaxine and its impurities K. Palanivel, D. Sivakumar, S. Sivapriya, S. Priyanka, M. Gopalakrishnan and H. Manikandan* Department of Chemistry, Annamalai University,Annamalainagar-608002 ,India. Author E-mail: [email protected] Abstract An improved process for synthesis of Venlafaxine from p-methoxyphenylacetonitrile with cyclohexanone using TBAI as phase transfer catalysis to give almost quantitative yields of cycloalkanols, further is reduced using Raney/nickel in methanolic ammonia, acetic acid and dimethylation using dimethyl carbonate/K2CO3 in DMF. The work is also included to identification, synthesis and characterization of process related impurities of venlafaxine
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